Photochemical internalization method

Procédé d'internalisation photochimique

Abstract

L'invention concerne des procédés visant à introduire des médicaments dans des cellules qui sont situées dans des cavités corporelles. L'invention concerne en particulier un agent photosensibilisant destiné être utilisé dans un procédé visant à introduire une molécule de médicament dans le cytosol d'une cellule située dans une cavité corporelle, ce procédé consistant à mettre en contact la cellule avec l'agence photosensibilisant et la molécule du médicament, et à irradier la cellule d'une lumière ayant une longueur d'onde efficace pour activer l'agent photosensibilisant. Ces procédés sont particulièrement appropriés pour être utilisés dans l'administration de médicaments cytotoxiques permettant de traiter le cancer, notamment le cancer de la vessie, le cancer des ovaires, le cancer du col de l'utérus, le cancer du poumon, le cancer du cerveau, le cancer colorectal et les cancers de la cavité buccale et nasale.
The invention relates to methods of introducing drugs into cells which are located in body cavities. In particular, it provides a photosensitizing agent for use in a method of introducing a drug molecule into the cytosol of a cell located within a body cavity, said method comprising the step of contacting said cell with said photosensitizing agent and said drug molecule, and irradiating the cell with light of a wavelength effective to activate the photosensitizing agent. Such methods are particularly suitable for use in the delivery of cytotoxic drugs in the treatment of cancer, especially bladder cancer, ovarian cancer, cervical cancer, lung cancer, brain cancer, colorectal cancer and cancers of the oral and nasal cavity.

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Patent Citations (4)

    Publication numberPublication dateAssigneeTitle
    WO-0244396-A1June 06, 2002Pci Biotech AsPhotochemical internalization for delivery of molecules into the cytosol
    WO-03020309-A2March 13, 2003Pci Biotech As, RIMINGTON, Greta, Jones, ElizabethCompound
    WO-2010001102-A2January 07, 2010Pci Biotech AsProcédé
    WO-2011018635-A2February 17, 2011Pci Biotech As, Golding, LouiseCompositions photosensibilisantes

NO-Patent Citations (4)

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