New molecular markers for detection of squamous cell carcinomas and adenocarcinomas and high-grade precursor lesions thereof

Nouveaux marqueurs moléculaires pour la détection de carcinomes de cellules squameuses et d'adénocarcinomes de cellules squameuses et lésions précurseurs de haut degré de ceux-ci

Abstract

La présente invention porte sur de nouveaux marqueurs pour la détection d'un carcinome et/ou d'un adénocarcinome de cellules squameuses induit par HPV ou de poumon et sur des lésions précurseurs de haut degré de ceux-ci. Ces marqueurs comprennent les gènes de la présente invention. La détection peut avoir lieu par détection de la sur expression ou de la régulation négative desdits gènes soit par un dosage d'acide nucléique, soit par des dosages pour les protéines obtenues par lesdits gènes.
The present invention provides for new markers for the detection of HPV-induced or lung squamous cell carcinoma and/or adenocarcinoma and high-grade precursor lesions thereof, comprising the genes of the present invention. Detection can take place by detection over expression or down regulation of said genes either by nucleic acid assay or by assays for the proteins produced by said genes.

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